Sydney residents who are not vaccinated against COVID-19 risk being barred from various social activities even when they are freed from stay-at-home orders in December, New South Wales state Premier Gladys Berejkilian warned on Tuesday.

Berejkilian said people who choose not to be vaccinated could be barred entry to shops, restaurants, and entertainment venues even after the state lifts all restrictions against them on December 1.

"A lot of businesses have said they will not accept anyone who is unvaccinated," Berejiklian told Seven News on Tuesday.

"Life for the unvaccinated will be very difficult indefinitely."

Under a roadmap to exit lockdown in Australia's biggest city, unvaccinated people are already subject to delays in freedoms that will be gradually granted to inoculated citizens between October 11 and December 1. Pubs, cafes, gyms, and hairdressers will reopen to fully vaccinated people on October 11 in New South Wales, home to Sydney, and more restrictions will be relaxed once the state's 80 percent adult population becomes fully vaccinated, expected by the end of October.

Federal Health Minister Greg Hunt welcomed the roadmap to exit lockdown in Australia and urged people to get vaccinated as soon as possible.